Role of Omega-3 and Vitamin B6 in Cancer Prevention

Role of Omega-3 and Vitamin B6 in Cancer Prevention A critical analysis of the role of omega-3 and vitamin B6 in cancer prevention: current evidence, proposed mechanisms and future directions Abstract: A critical analysis of the role of omega-3 and vitamin B6 in cancer prevention: current evidence, proposed mechanisms and future directions Cancer is a leading cause of death worldwide and according to the World Health Organization(WHO accounted for 8.2 million deaths in 2012(1). The complex and dynamic nature of cancer is evident, however 30% of cancers could be prevented by modifying factors such as diet, not smoking, physical activity and moderate use of alcohol(2). Scientific evidence suggests that nutritional supplementation of some nutrients can affect the risk of different cancers. For the purposive of this essay I will perform a critical analysis of the role of omega-3 and vitamin B6 in cancer prevention by reviewing the current evidence, proposed mechanisms and investigating the future directions of omega-3 and vitamin B6 use in cancer prevention. Omega-3(n-3) and omega-6(n-6) polyunsaturated fatty acids(PUFAs) are essential fatty acids that cannot be made by the human body and therefore must be obtained from the diet. The use of n-3 PUFAs in a number of chronic diseases such as coronary artery disease, psoriasis, irritable bowel syndrome and rheumatoid arteritis has been associated with health benefits. Increasing evidence from animal and in vitro studies indicate that n-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic(DHA) acid play a role in inhibiting cancer progression(3). However epidemiological data on the association between n-3 PUFA intake and cancer risk appears to be somewhat less consistent. High fat intake, typically seen in western diets is associated with an increased risk for cancer development. N-3 PUFAs are an exception as studies have found that n-3 PUFAs have protective functions in prostate, pancreatic, breast and colon cancer. Western diets typically contain a high n-6 to n-3 ratio which has been found is positively associated with prostate cancer development. A study carried out in Jamaican men who had a high ratio of dietary n-6 to n-3 ratio, found that n-6 PUFAs was positively correlated with prostate carcinogenesis while n-3 PUFAs inhibited cancer growth(4). In agreement with this study a case control study of 79 prostate cancer cases and 187 controls, found a high ratio of n-6 to n-3 PUFAs increased the overall risk of prostate cancer in white men and possibly increase the risk of a high grade prostate cancer in all men(5). Population based studies have found that the use of n-3 PUFAs are protective against cancer development. A population based prospective cohort study of 90,296 subjects found that a diet rich in n-3 fish or n-3 PUFA appeared to protect against the development of hepatocellular carcinoma (6). In agreement with this study a population-based prospective study in Japan found an inverse relationship between n-3 PUFA intake and the risk of cancer in the proximal site of the large bowel(7). However not all studies have found beneficial effects of the use of n-3 PUFAs in cancer prevention. A French study comprising of over 56,000 women, who were followed for eight years found no associated between n-3 PUFA and breast cancer risk(8). Numerous mechanisms have been proposed for the beneficial effects of n-3 PUFAs in cancer prevention. PUFAs are capable of influencing the fatty acid composition of glycerophospholipids in cell membranes. N-3 PUFAs can replace n-6 PUFAs in glycerophospholipids(9) and a high n-3 to n-6 ratio has been found to affect cell membrane signalling. Lipid rafts are important signalling domains within the cell membrane which contain receptors such as epidermal growth factor receptor(10). As DHA has a poor affinity for cholesterol in lipid rafts it can supress raft associated signal transduction(10). This is important as in many cancers signalling pathways can be over activated. It has also been suggested that n-3 PUFAs may induce apoptosis and reduce proliferation in human cancer cells by decreasing signalling through AKT/NFkB and by modulating the PI3k/AKT/p38 MAPK pathway(11). N-3 PUFAs are involved in the suppression of arachadonic acid (4n-6) derived eicosanoids, which are involved in cellular growth, cell differentiation and have proinflammatory effects (12). Arachadonic derived eicosanoids such as PGE2, have been positively linked to cancer (13), unlike EPA eicosanoids which have anticancer effects(14). As mentioned above incorporation of n-3 PUFAs into the phospholipid membrane replaces n-6 arachadonic acid precursors, decreasing arachadonic derived eicosanoids and increasing EPA eicosanoids. N-3 PUFAs have also been found to supress cyclooxygenase-2 (15), which has anti-tumour affects as COX-2 down regulates apoptotic pathways(16). This is in contrast to n-6 PUFAs which have been found to upregulate COX-2(17). It is also interesting to note that in breast, colon and prostate cancer COX-2 is overexpressed (18, 19). Taking this into account it is likely that suppression of COX-2 by n-3 PUFAs may be a preventative measure in these cancers. In conclusion there is evidence for the beneficial effects of n-3 PUFAs in cancer prevention, however due to inconsistencies in epidemiological data it is too early to recommend the use of n-3 PUFAs for cancer prevention. Possible explanations to explain these inconsistencies may be that population-based studies rely heavily on data from self-reported dietary PUFA intake. This form of data collection may poorly correlate with accurate PUFA intake. Another possible explanation is that the amount of n-3 PUFA administered in studies, may not be of a sufficient quantity to have a protective functions in cancer prevention. Further studies are needed to be carried out to account for the current variation in published studies before recommending n-3 PUFAs for cancer prevention. According to the latest report from the National Cancer Registry: Colorectal cancer (CRC) is the second most common cancer in both men and women in Ireland (20). Environmental factors such as diet have been identified as playing a role in the risk of CRC development. Preventability estimates from the World Cancer Research Fund show that 47% of cases of CRC in the UK can be prevented by modifying factors such as eating and drinking healthily, being physically active and maintaining a healthy weight(21). According to the National Health and Nutrition Examination Survey 2003-2004 24% of people (who did not take supplements containing vitamin B6) have suboptimal active B6 plasma concentrations (22). Vitamin B6 is a water soluble vitamin, which in its active form: pyridoxal 5’-phostphate (PIP) is involved in more than 100 coenzyme reactions, including lipid, carbohydrate and protein metabolism(23). Vitamin B6 may play a role in CRC prevention through its role in one carbon related DNA synthesis and methylation(24). Vitamin B6 has also been shown to reduce the formation of nitric oxide(25), inhibit angiogenesis(26) and reduce oxidative stress(27), creating an unfavourable environment for tumour development. Despite the mechanistic evidence supporting for the role of vitamin B6 in CRC cancer prevention, epidemiological evidence has been inconsistent. A meta-analysis of 9 studies carried out between 2002-2009 on Vitamin B6 intake in relation to CRC risk, found inconsistent results with both an inverse and positive association(28). The same meta-analysis included four nestled case-control studies investigating serum PLP on CRC risk. All four studies found an inverse relationship between PLP levels and CRC risk, with an overall reduced risk of CRC for every 100-pmol/mL increase in serum PLP(28). In the 9 studies of vitamin B6 intake and CRC risk it seems that highest vs lowest category of vitamin B6 intake was most important. When the study’s results were pooled together, a 21% significant reduction in CRC risk was found when comparing high vs low vitamin B6 intake in studies with a wider range of exposure (>1.5-mg difference)(28). A different study prospectively followed up 26,440 women and 44,410 men to assess whether a higher vitamin B6 intake in the remote past(12-16years prior to diagnosis) was more strongly associated with a lower risk of developing CRC than an intake in the recent past (4 years prior to diagnosis)(23). The results of this study did not support a strong role of vitamin B6 intake in preventing CRC development. However most of the participants were relatively well nourished, with only 5-10% of people having a vitamin B6 intake below the recommended daily allowance(23). This limited the study as it is not the most accurate measures of determining the potential effects on suboptimal vitamin B6 on CRC risk. The Japan Public Health Centre-based Prospective study investigated the association of dietary folate, vitamin B6, vitamin B12 and methionine on CRC risk(29). The study included 81,184 participants (38,107 men and 43,077 women) who were followed from 1995-98 to the end of 2002. A significantly inverse relationship between vitamin B6 intake and CRC was found in men. Men in the highest quartile of vitamin B6 intake had a 35% decreased risk of CRC compared with men in the lowest quartile. No association was found in vitamin B6 intake and CRC in women. Interestingly a higher intake of vitamin B6 appeared to be beneficial in men with higher alcohol intake. The study found that the risk of CRC associated with alcohol intake was significantly higher in those who had a low vitamin B6 intake, however this risk was found to decrease in those who had a higher vitamin B6 intake(29). In conclusion there is evidence to suggest that vitamin B6 may play a role in CRC prevention, however it appears that plasma PLP appears to be more strongly linked to a reduced risk in CRC. Studies investigating the effect of vitamin B6 intake on CRC risk appear to be inconsistent. In contrast studies on PLP have found higher plasma PLP CRC risk by 30-50%(23). It is also important to note that studies have found that individuals with higher activity levels, higher dietary intakes of folate and calcium and individuals who do not smoke have higher vitamin B6 levels and a decreased risk of CRC(23). In these individuals it is difficult to determine if it is these healthier behaviours or the increased B6 levels that decreases CRC risk. It is also difficult to assess the impact of dietary vitamin B6 on its own on CRC risk, as most foods containing vitamin B6 contain various other nutrients such as folate and vitamin D. Further studies are needed to be carried out to explain the current inconsistencies in the use of vitamin B6 and CRC risk before vitamin B6 can be recommended as a preventive measure. 1.International Agency for Research on Cancer WHO. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence in 2012 2012. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. 2.Organization WH. Cancer fact sheet 2014 [updated February 2014]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/index.html. 3.Parada B, Reis F, Cerejo R, Garrido P, Sereno J, Xavier-Cunha M, et al. Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer. BioMed research international. 2013;2013:368178. 4.Ritch CR, Wan RL, Stephens LB, Taxy JB, Huo D, Gong EM, et al. Dietary fatty acids correlate with prostate cancer biopsy grade and volume in Jamaican men. The Journal of urology. 2007;177(1):97-101; discussion 5.Williams CD, Whitley BM, Hoyo C, Grant DJ, Iraggi JD, Newman KA, et al. A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutrition research (New York, NY). 2011;31(1):1-8. 6.Sawada N, Inoue M, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, et al. Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma. Gastroenterology. 2012;142(7):1468-75. 7.Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, et al. Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study. International journal of cancer Journal international du cancer. 2011;129(7):1718-29. 8.Thiebaut AC, Chajes V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, et al. Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. International journal of cancer Journal international du cancer. 2009;124(4):924-31. 9.Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, et al. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. 2013;34(9):1968-75. 10.Turk HF, Barhoumi R, Chapkin RS. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PloS one. 2012;7(6):e39682. 11.Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast cancer research and treatment. 2005;92(2):187-95. 12.Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. The American journal of clinical nutrition. 2004;79(6):935-45. 13.Cheuk BL, Chew SB, Fiscus RR, Wong PY. Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. Biology of reproduction. 2002;66(2):374-80. 14.Cockbain AJ, Volpato M, Race AD, Munarini A, Fazio C, Belluzzi A, et al. Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid. Gut. 2014. 15.Hamid R, Singh J, Reddy BS, Cohen LA. Inhibition by dietary menhaden oil of cyclooxygenase-1 and -2 in N-nitrosomethylurea-induced rat mammary tumors. International journal of oncology. 1999;14(3):523-8. 16.Rose DP, Connolly JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacology therapeutics. 1999;83(3):217-44. 17.Badawi AF, Archer MC. Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. Prostaglandins other lipid mediators. 1998;56(2-3):167-81. 18.Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999;18(55):7908-16. 19.Dempke W, Rie C, Grothey A, Schmoll HJ. Cyclooxygenase-2: a novel target for cancer chemotherapy? Journal of cancer research and clinical oncology. 2001;127(7):411-7. 20.Registry NC. Cancer In Ireland: Annual report of the National Registry. 2013. 21.Fund WCR. Policy and Action for Cancer Prevention. Food, Nutrition, and Physical activity: a Global Perspective. 2009 updated 2011. 22.Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. The American journal of clinical nutrition. 2008;87(5):1446-54. 23.Zhang XH, Ma J, Smith-Warner SA, Lee JE, Giovannucci E. Vitamin B6 and colorectal cancer: current evidence and future directions. World journal of gastroenterology : WJG. 2013;19(7):1005-10. 24.Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. The journal of nutrition, health aging. 2002;6(1):39-42. 25.Komatsu S, Watanabe H, Oka T, Tsuge H, Kat N. Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. Journal of nutritional science and vitaminology. 2002;48(1):65-8. 26.Matsubara K, Mori M, Matsuura Y, Kato N. Pyridoxal 5-phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay. International journal of molecular medicine. 2001;8(5):505-8. 27.Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free radical biology medicine. 2001;30(3):232-7. 28.Larsson SC, Orsini N, Wolk A. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA : the journal of the American Medical Association. 2010;303(11):1077-83. 29.Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. The Journal of nutrition. 2007;137(7):1808-14.

Ap World History Units 1-3 Study Guide

Unit One 1. Consequences of the Neolithic Revolution didn’t includeEnd of hunting-gathering societies2. Most scholars believe that, during the Paleolithic Age, social organization was characterized byA rough social equality3. The earliest metal worked systemically by humans areCopper4. The spread of the Bantu-speaking peoples over southern Africa can be best explained by theirKnowledge of agriculture5. Characteristics of complex civilizationsSpecialization of laborTrade and cultural diffusionWritten languagesComplex political order and power6. Evidence proves that the MesopotamiansTraded extensively with peoples as far away as Anatolia, Egypt, & India7. Major effect of Neolithic RevolutionThe establishment of sedentary village communities8. Conditions for women in MesopotamiaGrew increasingly worse over time9. The division of the ancient people into social and gender hierarchies was first made possible byRise in agricultural production10. Ethical monotheism was the tradition of theHebr ews11. Hammurabi’s code was based on the concept of â€Å"lex talionis† but the punishments were shaped byThe social standing of the accused2. The Hittites who were the most influential ancient Indo-European migrants into southwest Asia are credited forHorse-drawn chariotsMetallurgyMigrating from southern RussiaDefeating the Babylonians13. The society who began the custom of embalming to preserve the body for its life after deathEgypt14. Which metal was most important in transforming agricultural societies into large urban civilizations?Iron15. In which society did women enjoy the most freedom and opportunity?Egypt16. In tribes which, as early as 3000 BCE, began to spread their language and agricultural techniques throughout Africa were theBantu17. The Chinese philosophy that promoted strict social and political control was* Legalism18. Social distinctions in Early River Valley civilizations were* Less pronounced than in Neolithic19. By spreading their language across a huge stretch of Africa, the Bantu played a role similar to that played by* Indo-Europeans20. The Bantu probably began their migrations because of* Population pressures21. Much of the early Harappan history remains a mystery because* The archeological remains are under water22. The biggest military advantages of the Indo-Europeans was* Their horses23. Most of our information about the early Aryans comes from the* Vedas24. Correct groupings of early societies and their rivers* Mesopotamia – Tigris & Euphrates; Egypt – Nile; Harappan – Indus; China – Huang He25. Harappan society* Most of their houses featured private showers and toilets* They traded extensively with the Mesopotamians* They had social distinctionsThey produced representational art 26. Group that retained much more influence on family structure in China than in other early civilizations* The extended family27. The Chinese concept of the â€Å"Mandate of Heaven† was sometimes used to justify* Rebellion28. Early China enjoyed lasting direct long-distance trade with* None29. Ritual bloodletting was crucial to Maya rituals because* It was associated with rain & agriculture30. The most characteristic artistic creation of the Olmecs were* Colossal human heads sculpted with basalt31. The Aryans affected the Indian sub-continent by A common written language* Adding race to the caste system* Establishing the Silk Road trade* Advanced use of technology32. Which of the following mathematical concepts, essential for positional notation and the manipulation of large numbers, was invented by Mayan mathematicians?* Zero33. The ultimate source of wealth in any agricultural society is* Land34. This passage from the Upanishads explain what Hindu concept? â€Å"According as a man acts and walks in the path of life, so he becomes. He that does good becomes good; he that does evil becomes evil. †* Karma35. Which early Mesopotamian ruler believed that the gods had chosen to â€Å"promote the welfare of the people†¦ (and) to cause justice to prevail in the land†?* Hammurabi36. During the time of the Aryans the Indian political landscape was characterized by* A series of small kingdoms37. Contributions of the River Valley Civilizations* Metallurgy in agriculture, welfare and art* The wagon wheel* Written forms of communication* The calendar and the 60-second minute38. What two River Valley civilizations are most alike as far as their use of regionalism and the decentralization of political power?* Olmec and Chavin39. Confucian social order* Loyalty to the ruler* Filial obedience to one’s father* Respect of younger brother to older brother* Respect of husband to wife40. Women were important contributors to the agricultural revolut ion because they were likely the* Gender who gathered edible plants and grew various grains41. Shang and Zhou China originated the â€Å"Mandate of Heaven† primarily* As a way to demonstrate the divinity of the emperor42. The government structures of early Mesopotamia and Egypt* In both civilizations power was concentrated in the hands of a king who was considered a god43. The Chinese copied their chariots from* The steppe nomads44. The Period of Warring States refers to the * Chaotic last centuries of the Zhou dynasty 45. The early Chinese shipped textiles and metal goods to the ancestors of the Turks and Mongols in the steppes and received what in return?* Horses46. Which of the following is a key philosophical and religious element of Daoism?* Emphasis on harmony between humanity47. Which of the following describes the major effect of Bantu migrations?* Cultural commonalities in sub-Saharan Africa48. Confucius argued that* Educations is essential to becoming a refined gentleman49. The device the ancient Olmec build in order to trap silt carried by the numerous rivers passing through the Mesoamerican lowlands* Terraces50. The proper order from top to bottom of the original Aryan caste system?* Priests, warriors, farmers/merchants, laborers, polluted laborers51. One key role of the caste system which was unlike other systems of social inequality in the ancient world was that the caste system* Served to maintain order and stability as political systems did in Mesopotamia, Egypt, and China52. What p urpose do scholars believe paleolithic Venus figurines served? The figurines reflect a deep interest in fertility necessary for the generation of the new life 53. A key geographic difference between ancient Egyptian, Mesopotamian, Harappan, and Chinese society was thatEgypt and China were more isolated and therefore protected by their environment than there were the Mesopotamians or Harappans54. Olmec and Mesopotamian political traditions are an example of* Decentralized monarchy55. Because of the immense size of the Zhou state, its emperors were forced to* Institute a feudal system of the governmentUnit Two1. An important reason for the fall of the Roman, Han, and Gupta empires was * Intensified invasions and security issues along their frontiers 2. Before 500 C. E. Judaism and Hinduism were similar in that both * Had written scriptures and an ethical code to live by 3. In organizing their empire, Persian rulers relied heavily on techniques of administration from the * Mesopotamians 4. The Medes and Persians were originally * Indo-European tribes 5. The classic Persian governmental approach was * An enlightened an tolerant one 6. The Persian legal code was designed to * Codify laws of the subject peoples 7. The center of the Persian communications network was * The Royal Road 8. Basic tenets of Zoroastrianism that influenced later religions * The belief in heaven and hell * The encouragement of high moral standards * The doctrine that individuals will undergo a final judgment * The belief that each individual plays a key role in determining his or her spiritual destiny 9. The Qin and Han dynasties * Went further than the Persian emperors in their efforts to foster cultural unity 10. Confucian terms * Ren – benevolence * Xiao – filial piety * Dao – way * Junzi – superior individuals 11. The philosophy that criticized the social activism, and instead, proposed a life of reflection and introspection was * Daoism 12. What was the school of philosophical thought that returned order to China after the Period of Warring States? * Legalism 13. Qin Shihuangdi’s most important contribute to China was * Establishing a precedent for centralized imperial rule 14. The Han philosophy of rule was * A contribution of Qin policies of centralizations 15. In 124 B. C. E. , Han Wudi transformed China by * Establishing an imperial university 16. Which popular treatise emphasized humility, obedience, subservience, and devotion to their husbands as the virtues most appropriate for women? * Admonitions for Women 17. As the Han dynasty became more powerful and wealthy, * The gap between rich and poor grew dangerously large 18. The Indian political scene changed dramatically in 520 B. C. E. when new administrative techniques were introduced after the invasion of the * Persians 19. The rock and pillar edicts were issued by Ashoka 20. One of the biggest financial problems of the later Mauryan period was the ruler’s decision to * Debase the currency 21. Politically, the Guptas * Left local government and administration in the hands of their allies 22. The success and timing of trade, through the Indian Ocean basin, largely depended on * Understanding the rhythms of the monsoon winds 23. One of the biggest transformations of the caste system during this period was * The rise of guilds, which essentially served as jati 24. The greatest social contribution of the Jains was The fact that they did not recognize social hierarchies based on caste 25. When Krishna tells Arjuna, in the Bhagavad Gita, â€Å"Having regards to your own duty, you ought not to falter, for there is nothing better for a Kshatriya than a righteous battle,† he is referring to what Hindu principle? * Dharma 26. The political structure of the ancient Greeks * Usually considered of independent, autonomous city-states 27. The Greeks used the word polis to refer to the * The city-state 28. Athenian democracy was open to * All Athenian citizens 29. Events that occurred during the time of Pericles * Athenian democracy reached its high point Athens became the most sophisticated of the poleis * Athenian expansion and arrogance helped spark the Peloponnesian War * Athens underwent a massive building program 30. Affects that came about because of Greek colonization * An increase in the size and diversity of trade * The spread of Greek language and cultural traditions * A quickening of the tempo of social life * Increased contact with other societies 31. Consequences of the Neolithic Revolution * Incidence of disease increased * Widening gender differences * Rapid increase in human population * Increase in reliable food supply 32. In The Republic, Plato proposed that the true rulers of society should be * Philosopher kings 33. The Roman policy toward conquered peoples was * Generous with potential for citizenship 34. The Roman policy of toleration and respect for conquered peoples was most similar to the * Persians 35. The land route of the silk roads ran from the Han capital of _____________ to the Mediterranean port of _____________. * Chang’an; Antioch 36. Latifundia were * Enormous plantations worked by slaves 37. After naming himself dictator in 46 B. C. E. Julius Caesar * Launched large-scale building projects in Rome Extended Roman citizenship to peoples in the imperial provinces * Appointed some Gauls to the Roman senate * Seized the land from the conservatives and distribute it to his army veterans 38. The reign of Augustus inaugurated a period known as paxromana in which caused * Common coinage * Common language * Greco-Roman art * Stoicism 39. Foundations of Roman Law * The principle that defendants were innocent until proven guilty * The notion that defendants had a right to challenge their accusers before a judge in a court or law * The ability of judges to set aside laws that were inequitable 40. The information that Zhang Qian brought back encouraged Han Wudi to destroy the Xiongnu and lay out the foundations for the * Silk roads 41. The fact that by the first century C. E. southeast Asian kings called themselves rajas shows how they were influenced by the * Indians 42. By around the year 600 C. E. , the ravages of epidemic diseases had caused both the Mediterranean and Chinese populations decrease by * At least a quarter 43. In the year 184 C. E. , peasant discontent in China led to an uprising known as the * Yellow Turban rebellion 44. With the collapse in political order after the fall of the Han Empire, * Daoism and Buddhism became much more popular 45. The Roman Empire was divided into two parts by * Dio Cletian 46. The social distinctions in Early River Valley civilizations were * Did not exist as they did in pervious times 47. After the collapse of the western half of the Roman Empire, imperial authority survived for another thousand years in the * Byzantine Empire 48. Major effect of Bantu migrations * Cultural commonalities in sub-Saharan AfricaUnit 3: Part I1. Agricultural production increased throughout medieval Europe mainly esult of a * A heavier plow * Water and wind powered mills 2. Arabic conquests of Mesopotamia and Persia influenced the women in the Islamic world by making * Society more patriarchal 3. Characteristics of the medieval period of Europe * Political order through feudalism * Economic order through manorialism * Religious order through Church * Expanded trade and education 4. The expansion of communication and trade networks in Afro-Eurasia from 600 C. E. to 1450 C. E. resulted in the spread of what from South Asia? * Technological and scientific concepts such as decimal and zero 5. Foot binding is probably the best example of * The increasingly patriarchal nature of Chinese society 6. During the Tang and Song periods, the imperial â€Å"examination system† * Expanded and filled posts based on intellectual ability and merit 7. When comparing northern and southern India during the postclassical era, it can be stated that * The south suffered through far fewer invasions than the north did 8. The success of the Byzantine â€Å"theme system† was most dependent upon * Promoting rural agriculture with few imperial restrictions 9. Islam became very popular in India and within different segments of Hindu society because * It emphasized equality and it was less exclusionary than Hinduism 10. The term â€Å"samurai† describes men in feudal Japan who were most like these men in Europe * Knights 11. Gender relations up to 1000 C. E. * In some societies, women enjoyed more rights than in others 12. The impact of commercial trade during this period * Technology, crops and religious ideology spread from China in the east to Europe in the west while also connecting India, the Middle East and Africa’s Swahili coast 13. Constantinople Was constructed by Constantine * Allowed the imperial court to keep watch on the Sasanid Empire in Persia * Was built because the eastern half was the wealthier and more productive part of the empire * Allowed the imperial court to keep watch on Germanic tribes on the Danube 14. The items Marco Polo encountered at Kublai Khan’s court and described to Europeans * Paper money * Food stocks – noodles * â€Å"Black stones† – coal * Gunpowder 15. Middle Eastern trade in the period between 1000 to 1400 * A unified Islamic Empire which eliminated tariffs and encouraged trade 16. Justinian’s most significant long-term accomplishment * He regulated and established a new uniform legal code for his empire 17. Comparison of the political systems in western Europe and China during the time period 1000 – 1300 * Western Europe developed multiple monarchies while China maintained a single empire 18. After the fall of Rome, the only real institutions of learning in Western Europe were the * Christian monasteries 19. Hagia Sophia was * The magnificent church at Constantinople 20. Major public work that was first constructed by emperor Yangdi during the Sui Dynasty in China * The Grand Canal 21. A result of the Viking raids on Europe from the 8th to the 10th centuries was that * Europeans organized into feudalistic societies for protection 22. In 1054 the pope in Rome and the patriarch in Constantinople * Mutually excommunicated each other 23. Charlemagne * He expanded the Frankish territory * He supported education and literacy * He instituted the missi dominci * He established his capital in Aachen 24. Guilds during the Late Medieval period Admitted women as members 25. Relationships between Islam and the influence it received from other cultures * India – mathematics & economics * Persia – literacy works & politics * Greece – philosophy & medicine * China – paper, cotton & silk 26. The main Indian influence on Islamic thought was in the field of * Mathematics 27. Major result of the Christian Crusades * Europeans were introduced to new technology, trade and cultural exchanges 28. Common feature of most Middle Eastern, Asian and European societies during the period of 1000 to 1450 * A close association with religion 29. The most striking difference between the Tang and the Song dynasties affecting their survival was * The differing ways they chose to deal with nomads on their frontiers 30. The two major sources of stability during the Medieval period of Europe * Feudalism and the Catholic church 31. In regard to political structure, postclassical India * Developed no single centralized imperial authority 32. An invasion in 451 C. E. , by the White Huns, began the collapse of the * Gupta dynasty 33. In 711, the northern Indian area of Sind fell to the * Umayyad dynasty 34. The most important new crop introduced to China during the Tang and Song periods was * Fast-ripening rice 35. The primary difference between Shiite Muslims and Sunni Muslims is a disagreement over * The leadership of the Muslim community after Muhammad’s death 36. The Indian ruler Harsha was known for * His Buddhist faith and his benevolent treatment of his subjects 37. Legacy of the Vikings during the medieval period * Feudalism * Exploration * Warfare * Shipping technology 38. The Abbasid Dynasty differed from the Umayyad Dynasty in that * It was not a conquering dynasty 39. The Delhi sultans were Never able to expand their control beyond northern India 40. The Crusades by European Christians at the end of the eleventh century were motivated primarily by * Efforts to unite religious power and retake control of Jerusalem and the Holy Lands 41. An example of interaction among Indian, Arab and European societies by 1200 was the transfer of * Numerals and decimal system 42. The Tang planned to avoid the concentration of land by the wealthy by implementing the * New economic planning system 43. Zheng He was * The Chinese admiral who made seven journeys of exploration 44. Hindu temples Played an important role in the agricultural and financial development of southern India 45. Major reason for the rapid expansion of Islam during the 7th & 8th centuries * The advanced military technology of the Islam forces 46. India was a natural location for the establishment of emporia because of * Its central locations in the Indian Ocean basin 47. Achievements of the Early Middle Ages * A restoration of political order through a feudal system * Some economic recovery because of agricultural advancement * The creation of an institutional framework for the Christian church based in Rome 48. The adoption of the Neo-Confucianism by the Ming dynasty during the 14th century was primarily motivated by the * Need for competent government administrators 49. The Byzantine Empire achieved * The conversion of many Slavic peoples to Christianity 50. Islamic & Chinese empires in the postclassical period (700 – 1200 C. E. ) shared a characteristic of * Extensive urbanization & maritime trade 51. Most important effect of Islamic expansion on the civilizations of medieval Europe * The transmittal of Greek & Arab learning 52. The development and spread of Christianity and Buddhism both * Were outgrowths of other religions * Were aided in their spread by the trade networks * Developed monastic orders * Venerated people of high spiritual merit 53. In medieval society, political power was vested in * Local authorities 54. The most important relationship in feudalism was between * Lord and retainerUnit 3: Part 21. The largest empire of all time was created by the * Mongols 2. The Inca quipu was * A record keeping device consisting of small cords with knots 3. The political power of the khans was based on Indirect rule through the leaders of allied tribes 4. In an effort to strengthen the Mongol fighting forces, Chinggis Khan * Formed new military units with no tribal affiliations 5. Who made a famous pilgrimage to Meca in 1324 – 1325? * Mansa Musa 6. Khubilal Khan’s military and imperial pursuits * Had little success when he tried to conquer Vietnam, Cambodia, Burma, and Japan 7. Ethiopian Christianity * Retained both traditional African and Christian beliefs 8. The Mongols brought greater integration among Eurasian peoples by * Increased trade * Resettlement of conquered peoples Diplomatic missions 9. Devastation wrought by the bubonic plague played a key role in the fourteenth century collapse of the * Yuan dynasty 10. The introduction of a new crop about 400 C. E. encouraged a fresh migratory surge in Africa. What was the crop? * Bananas 11. The first European nation to dominate trade with Asia was * Portugal 12. By the middle of the first millennium B. C. E. , the Bantu had begun to produce * Iron 13. The late fourteenth century Turkish ruler who weakened the Golden Horde, sacked Delhi, and launched campaigns in southwest Asia and Anatolla, was * Tamerlane 14. One of the central factors in the establishment of trans-Saharan trade was * The domestication of the camel 15. By the tenth century C. E. , the kings of Ghana had converted to * Islam 16. Foundations of Mali’s power * Control over trans-Saharan trade * A strong cavalry * A series of powerful kings 17. During the period of Mongol domination, * Long-distance trade became much less risky 18. In regard to political structure, the Aztec empire * Had no elaborate bureaucracy 19. Just as the kingdoms of west Africa depended on trans-Saharan trade, the kingdoms of east Africa depended on * Indian Ocean trade 20. The Ilkhanate in Persia began a rapid decline in the 1200s * After the government issued paper money 21. Since there was no concept of private ownership of land in sub-Saharan Africa, * Slave ownership formed an important aspect of determining personal wealth 22. Historians estimate that between 750 and 1500 C. E. , the number of slaves transported north as part of the trans-Saharan slave was * Ten million 23. In the five centuries after the year 1000 C. E. , the peoples of the eastern hemisphere * Traveled and interacted more intensively than ever before 24. By 1750, all parts of the world participated in a global trade network in which European’s played dominant roles except * Australia 25. Khubilal Khan employed Marco Polo in administrative posts * Because he did not entirely trust his Chinese subjects 26. When Pope Innocent IV sent envoys to invite the Mongols in an alliance against the Muslims, * The khans declined and in turn told the Christians to submit to Mongol rule or be destroyed 27. Ibn Battuta was able to travel so extensively because * His religious and legal training allowed him to serve as qadi 28. Product that had a new impact during this period of increasing interaction * Silk 29. The North American Indian societies * Possessed no form of writing 30. Common results of a bubonic plague * A decline in trade * A decline in population * Peasant rebellions caused by efforts to freeze wages 31. The Yongle Encyclopedia * Represented the Ming rulers’ interest in supporting native Chinese cultural traditions 32. Central to the Renaissance thought beginning in northern Italy was * A fascination with the ancient world 33. Mali became the wealthiest kingdom in sub-Saharan Africa because of * Its control of the gold trade 34. Humanist moral philosophers believed that * People could lead morally virtuous lives while participating in the world 35. Under Spanish rule of the Philippines, the native population * Was pressured to convert to Roman Catholicism 36. In regard to exploration, Prince Henry was to Portugal what _________ was to China. * Wan Li 37. The Toltec state collapsed by around 1175 because * Of a combination of civil conflict and nomadic invasion 38. The chinampa system refers to * The Aztec practice of dredging fertile muck from the lake’s bottom 39. In regard to gender issues in sub-Saharan Africa, Women had more opportunities open to them than did their counterparts in other societies 40. Rulers among the Mexica were chosen by * A council made up of the most successful warriors 41. A Mexica woman who died in childbirth * Won the same fame as warriors who died valiantly in battle 42. The Aztecs viewed human sacrifice * As an essential ritual to ensure the world’s survival 43. North American societies * Developed on a relatively small scale 44. In regard to political structure, the early Bantu societies * Governed themselves mostly through family and kinship groups 45. The Inca imposed order By taking hostages from the conquered tribes’ ruling classes 46. Hallmark of Hongwu’s rule * The reestablishment of Confucian education * Extensive use of the civil service system * The reestablishment of the civil service system 47. The cultural and religious traditions of the Australian aborigines * Did not diffuse much beyond their own regions 48. During the early modern era, which of the following non-European peoples explored the Indian Ocean? * Chinese 49. In sub-Saharan Africa, an age grade was * A publicly recognized group that performed tasks based on their strength and maturity 50. Main inspirations for European exploration * The desire to conquer China and India 51. The invasions of the nomadic Turkish and Mongol tribes between the eleventh and fifteenth centuries * Facilitated greater cross-cultural communication and integration 52. Reasons for the European interest in finding a maritime trade route * The spread of the bubonic plague made the silk roads more dangerous * The high prices charged by Muslim merchants * The demand in Europe for items such as Indian pepper and Chinese ginger 53. The Reconquista came to an end in 1492 when * The Muslim kingdom of Granada fell to Spanish Catholic forces 54. Chinese inventions * Sternpost rudder and magnetic compass 55. The profitable merchandise that Vasco da Gama purchased in India was made up of * Pepper and cinnamon 56. The Portuguese dominance of trade was dependent on their ability to * Force merchant ships to call at fortified trading sites and pay duties 57. In the end, Portugal was unable to maintain its early domination of trade because * It was a small country with a small population 58. Advantages that the English and Dutch had over the Portuguese * They possessed faster, cheaper, and more powerful ships * They created joint-stock companies * They were wealthier countries 59. The Dutch policy in Indonesia was * To control the production of spices 60. The country that finished the Seven Years’ War with global hegemony was * England 61. In the long term, the Columbian exchange * Increased world population because of the spread of new food crops 62. From 1500 to 1800, the largest contingent of migrants consisted of * Enslaved Africans

Memo regarding gun violence and illegal use of narcotics Free Essay Example, 1250 words

There may develop disputes among the dealers involving the payment of debts and the heavy competition witnessed that may result in gun violence (Decker and Alarid 48). Solutions to These Problems Role of Scientists In an attempt to curb all these issues, there should be the incorporation of very strict measures. One of the ways is by rooting out the basic factors that bring about illegal use of narcotics and gun violence. Narcotics use is associated with the need to alter sobriety and have fun for most people. However, many of them have side effects including hallucinations and other associated mental issues. It is advisable to bring in a group of specialized scientists to help in the identification of the drug components that bring about this odd behavior. With this vital information, the administration should go ahead to legalize the drugs that are free of these substances. However, these step and method of control are advisable for the addicts only on their way to recovery, and hence its lack of perfection as a method. Role of Doctors The medical unit should be educated and advised to prescribe these narcotics only in time of dire need. We will write a custom essay sample on Memo regarding gun violence and illegal use of narcotics or any topic specifically for you Only $17.96 $11.86/pageorder now Apart from that, the doctors and pharmacists should prescribe less strong substances for the ease of pain. This resolution method relies on the fact that only after the first prescription of these narcotics by the respective medical personnel, do the patients find the urge to use them repeatedly, hoping to ease their problems that eventually lead to addiction. Role of Psychologists The convening of occasional workshops by psychologists where people attend for free to get educated on the hazards of using these narcotics and the general danger that they bring to society as a whole should receive encouragement. The link to violence should be one of the key points discussed during these workshops. Awareness of the situation and identifying the various threats is sure to reduce the likelihood of more people joining the drug syndicates and, consequently, having a safer, more reputable and hospitable environment (Cefrey 26). Role of the State The other method of control should be the allocation of a specific amount of money towards the construction and the equipping of a modern-day rehabilitation center. Many people find it hard to quit the use of these drugs due to the fact that they are still in contact with their dealers, and the environment through which they are expected to recover is not conducive enough. The allocation of these funds would seem rather expensive, and this appears as a shortcoming, but looking at the eventual result, the move will lead to the creation of more productive members of society that are rather needed in these trying economic times.

Stem Cells The Most Important Cells in the Medical Field

Medical research and therapies are advancing at an incredibly fast rate and stem cells represent a bright future in this field of study. Stem cells have properties that set them apart from all other cell types and make them very useful for therapies and treatments. They have the ability to divide and differentiate into any type of cell within the body. They are essential to the functioning of the human body because they repair and replace dying cells and damaged tissues. There are two types of stem cells, embryonic stem cells and somatic (adult) stem cells. They differ in their properties and exist at different stages of development in the body. Currently stem cells are being used in several treatments such as bone marrow transplantation and cancer treatment. There are also numerous other applications for stem cells in the medical field. They are becoming some of the most important cells in advancing treatment for diseases. Stem cells are essential not only for normal bodily functions but also for the advancement of therapies and fighting disease. There are two main types of stem cells present in the body. There are embryonic stem cells and adult stem cells, also known as somatic stem cells. As their names imply these different kinds of stem cells are present in the body at different stages of development. Embryonic stem cells exist when the embryo is still growing and developing. Adult stem cells on the other hand exist in the body both in childhood andShow MoreRelatedThe Study of Stem Cells Essay873 Words   |  4 PagesDr. James Till, a Biophysicist, and Ernest McCulloch, a Hematologist, proved that stem cells exist. Stem cells are considered important by many scientists for their trait of being able to adjust and develop into any kind of tissue. The study of stem cells has been mainly the interest of Biologist, however, Chemists have also had an interest in the advancement of stem cells. 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Stem cells promise future cures for many currentlyRead MoreThe Debate Of Stem Cell Research1519 Words   |  7 Pagestopic of stem cell research to the table to inform you on a topic you most likely know nothing about. According to the bible the strong need to bear with the failings of the weak. Why should we please ourselves if we don’t care for stem cell research? Among one of the, if not the most, controversial topics of our time comes one medical science tha t can save lives if legalized nationwide. We are talking about stem cells of course, and why the allowance of these basic cells in common medical practiceRead MoreResearch On Stem Cell Research1731 Words   |  7 PagesProhibit Stem Cell Research Many individuals believe that the beginning of stem cell research began in the early 2000s. However, the history of stem cell research can be traced back to the mid 1800s, when the make-up of human life, known as cells, were discovered (Solter 2006). 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